Abstract

The VAERS (Vaccine Adverse Event Reporting System) database was studied in this study, 1990-2010; cases that specified hospitalization or death were identified in 38.801 reports of newborns. Based on the types of vaccines reported, the actual number of vaccine doses administered, from 1 to 8, was summarized for each case. Linear regression analysis of hospitalization rates as a function of (a) number of reported vaccine doses and (b) patient age produced a linear relationship with r2 1/4 0.91 and r2 1/4 0.95, respectively. The hospitalization rate increased linearly from 11,0% (107 of 969) for 2 doses to 23,5% (661 of 2817) for 8 doses and decreased linearly from 20,1% (154 of 765) for children of age <0,1 years to 10,7% (86 of 801) for children aged 0,9 years. The rate ratio (RR) of the mortality rate for 5-8 vaccine doses at 1-4 vaccine doses is 1,5 (95% confidence interval (CI), 1,4-1,7), indicating a statistically significant increase from 3,6% (95% CI) , 3,2-3,9%) deaths associated with vaccine doses 1-4 to 5,5% (95% CI, 5,2-5,7%) associated with vaccine doses 5-8. Male to female mortality was 1,4 (95% CI, 1,3-1,5). Our results show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are administered annually to millions of children, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that children could receive. Finding ways to increase vaccine safety should be the top priority.

Conclusions

VAERS is one of the largest databases containing adverse reactions reported in temporal association with vaccination. While some adverse events reported to VAERS may not be related to recent vaccination, the VAERS database is an important postmarketing safety surveillance tool that is periodically analyzed by the CDC, the FDA and other vaccine researchers to find out about potentially adverse vaccination trends. . Using linear regression, several statistically significant trends were derived from the VAERS database: (a) a positive correlation between hospitalization rates and the number of vaccine doses (r2 1/4 0.91); (b) a negative correlation between hospitalization rates and age (r2 1/4 0,95); (c) an increase in the mortality rate associated with 5-8 vaccines related to 1-4 vaccines; (d) a decrease in the mortality rate associated with children aged 0,5 to <1 year compared to those aged <0,5 years; and (e) an infant mortality ratio between 1,4 males and females. These trends not only have biological plausibility, but are supported by evidence from clinical cases, case series and other studies that use completely different methodologies and specific population cohorts.
No studies have been conducted to determine the safety (or efficacy) of the administration of multiple vaccine doses in a variety of combinations as recommended by the CDC guidelines. Our results show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths reported to VAERS. In addition, younger children were significantly more likely than older children to be hospitalized or die after receiving vaccines. Since vaccines are administered to millions of children every year, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that children can receive; Universal vaccine recommendations need to be supported by these studies.
The adverse reaction trends seen in VAERS have important implications for vaccine recipients and healthcare professionals. Finding ways to increase cow safety should be the top priority. Further inspection of potential correlations between increases in vaccine doses, hospitalization and death is essential. Health policy makers have an obligation to determine whether vaccination programs are achieving the desired goals.

Source: https://www.ncbi.nlm.nih.gov/pubmed/22531966